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[Ebastine : treatment of perennial rhinitis in the child]

V Benavente1, J L Eseverri, J Botey

  • 1Service d'allergie et immunologie clinique pédiatrique, hôpital universitaire materno-infantile, Vall d'Hebron, Barcelone.

Allergie Et Immunologie
|October 1, 1996
PubMed

Insights

Ebastine effectively controlled persistent rhinitis symptoms in children by reducing allergic responses and improving clinical scores. This H1 receptor antagonist demonstrated good tolerance with no observed central nervous system side effects.

Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Pediatrics

Background:

  • Persistent rhinitis significantly impacts children's quality of life.
  • Histamine H1 receptor antagonists are key in managing allergic conditions.
  • Evaluating Ebastine's efficacy and safety in pediatric persistent rhinitis is crucial.

Purpose of the Study:

  • To assess Ebastine's effectiveness in alleviating persistent rhinitis symptoms in children.
  • To evaluate the impact of Ebastine on allergic skin test responses and nasal/conjunctival provocation tests.
  • To determine the safety profile and tolerance of Ebastine in the pediatric population.

Main Methods:

  • A 30-day open-label study involving 30 children with persistent rhinitis.
  • Diagnosis confirmed via clinical history, skin prick tests, nasal/conjunctival provocation tests, and IgE levels.
  • Clinical scores, skin tests, provocation tests, and adverse events were monitored throughout the study and post-treatment.

Main Results:

  • Significant reduction or disappearance of weals in histamine and specific antigen skin tests.
  • Decreased response in nasal and conjunctival provocation tests.
  • Clinical improvement observed in 24 out of 30 patients; 6 showed no response.
  • No central nervous system (CNS) side effects were reported, indicating good drug tolerance.

Conclusions:

  • Ebastine effectively improves clinical symptoms of persistent rhinitis in children.
  • The drug inhibits skin test reactivity and reduces shock organ sensitivity.
  • Ebastine is well-tolerated with a favorable safety profile in pediatric patients.

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