[Solid pseudopapillary tumors of the pancreas]

Area of Science:

• Oncology
• Gastroenterology
• Surgical Pathology

Background:

• Solid pseudopapillary tumors (SPTs) of the pancreas are rare neoplasms with unclear histogenetic origins.
• These tumors predominantly affect young women, often presenting as large, asymptomatic masses up to 10 cm.
• Metastasis is uncommon, and SPTs typically displace the main pancreatic duct without causing stenosis.

Purpose of the Study:

• To describe the clinical presentation, surgical management, and outcomes of three female patients with solid pseudopapillary tumors of the pancreas.
• To highlight the characteristic features of SPTs, including their size, location, and relationship with the pancreatic duct.
• To evaluate the efficacy of surgical resection as a curative treatment for SPTs.

Main Methods:

• Retrospective case series analysis of three female patients diagnosed with solid pseudopapillary tumors of the pancreas.
• Detailed review of clinical data, imaging findings, surgical procedures, and histopathological reports.
• Long-term follow-up assessment for tumor recurrence and patient survival.

Main Results:

• All three patients presented with large pancreatic masses (up to 10 cm) and were successfully treated with curative surgical resection.
• Tumor infiltration into pancreatic parenchyma or adipose tissue was observed in two cases, but no lymph node or distant organ involvement occurred.
• Patients remained alive and disease-free for up to 8 years post-surgery, indicating favorable long-term outcomes.

Conclusions:

• Solid pseudopapillary tumors of the pancreas, despite their large size, are amenable to curative surgical resection.
• The characteristic displacement of the pancreatic duct without stenosis is a key feature differentiating SPTs from other pancreatic malignancies.
• Surgical management provides excellent long-term survival and disease control for patients with solid pseudopapillary tumors of the pancreas.