[Extraneural metastasizing oligodendroglioma (author's transl)]

Area of Science:

• Neuro-oncology
• Pathology

Background:

• Oligodendroglioma is a primary brain tumor arising from oligodendrocytes.
• Right parietal oligodendroglioma presents a rare but aggressive clinical course.

Observation:

• A 40-year-old male presented with a right parietal oligodendroglioma.
• Surgical tumor removal was attempted two months after symptom onset.
• Tumor invasion into the falx cerebri was noted during a second craniotomy four years later.

Findings:

• The oligodendroglioma invaded the sagittal sinus and contralateral left hemisphere.
• Necropsy confirmed extensive local invasion and distant metastases.
• Metastatic sites included the lung, lymph nodes, vertebra, and femur.

Implications:

• This case underscores the aggressive nature and metastatic potential of some oligodendrogliomas.
• Advanced invasion and widespread metastasis indicate a poor prognosis despite surgical intervention.
• Further research into the molecular mechanisms driving oligodendroglioma invasion and metastasis is warranted.