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Transient expression of the basic helix-loop-helix protein NSCL-2 in the mouse cerebellum during postnatal
1Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523, USA.
Brain Research. Molecular Brain Research
|February 1, 1996
Abstract:
The spatio-temporal expression of the basic helix-loop-helix transcription factor NSCL-2 was analyzed in the postnatal development of the murine brain by in situ hybridization. We found that NSCL-2 is transiently expressed in the cerebellum. NSCL-2 was found exclusively in the premigratory zone of the external granule layer where postmitotic neurons undergo initial stages of neuronal differentiation. NSCL-2 expression was not detected in mature neurons. This pattern of expression suggests that NSCL-2 is critical for the onset of neuronal differentiation, but not for the maintenance of the differentiated state.