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Olfactory bulbectomy increases prepro-galanin mRNA levels in the rat locus coeruleus
1Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892-1380, USA.
Brain Research. Molecular Brain Research
|February 1, 1996
Abstract:
The effects of olfactory bulbectomy (OBX) on galanin (GAL) gene expression in the locus coeruleus (LC) were examined with quantitative in situ hybridization histochemistry. OBX increased prepro-GAL levels 3 and 14 days after surgery, as compared to sham-operated controls. Levels of mRNA encoding prepro-neuropeptide Y (NPY) were unchanged, and levels of mRNA encoding tyrosine hydroxylase (TH) were elevated in the LC only on day 3. The results indicate that GAL gene expression in the LC increases after lesioning a terminal field.