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[Macro- and microcirculation study in diabetic patients]

M Corsi1, F Lacerna, A Borzone

  • 1Ospedale Civile, Civita Castellana, Viterbo.

Minerva Cardioangiologica
|November 1, 1996
PubMed
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Diabetic patients often develop early neuropathy, linked to arterial wall condition. This study correlates carotid/femoral stenosis and microcirculation in diabetics, revealing preclinical neuropathy prevalence.

Area of Science:

  • Vascular Medicine
  • Diabetology
  • Neurology

Background:

  • Diabetes mellitus is associated with widespread vascular complications affecting macrocirculation and microcirculation.
  • Early detection of vascular damage in asymptomatic diabetic patients is crucial for preventing severe outcomes.

Purpose of the Study:

  • To investigate the correlation between carotid and femoral artery stenosis, ultrasound biopsy findings, and distal microcirculation parameters in diabetic patients.
  • To assess the prevalence of early, preclinical neuropathy in relation to arterial wall condition in diabetics.

Main Methods:

  • Prospective study of 90 asymptomatic diabetic patients (mean age 49 years, diabetes duration 15 years).
  • Assessment included ultrasound of carotid and femoral bifurcations, ultrasound biopsy, and laser-Doppler measurements of distal microcirculation.

Related Experiment Videos

  • Evaluation of veno-arteriolar reflex and ultrasound biopsy values (>25 considered significant).

    • Main Results:

    • 70% of diabetic patients exhibited an altered veno-arteriolar reflex.
    • Among those with an altered reflex, 30% had ultrasound biopsy values exceeding 25.
    • A direct proportionality was observed between preclinical neuropathy and the arterial wall condition.

    Conclusions:

    • Most diabetic individuals develop early, preclinical neuropathy.
    • The progression of this neuropathy is directly proportional to the state of the arterial wall.
    • Vascular examination, including microcirculation assessment, is vital in diabetic patient management.