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Experiences with morphine injected into the subarachnoid space in sheep
A E Wagner1, C I Dunlop, A S Turner
1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA.
Veterinary Surgery : VS
|May 1, 1996
Summary
Subarachnoid morphine in sheep undergoing stifle surgery did not improve recovery or reduce lameness. Instead, it caused adverse effects like hindlimb weakness and skin irritation, suggesting no benefit and potential harm.
Area of Science:
- Veterinary Surgery
- Anesthesiology
- Pharmacology
Background:
- Intrathecal morphine is used for postoperative pain management.
- The efficacy and safety of subarachnoid morphine in sheep undergoing stifle surgery require investigation.
Purpose of the Study:
- To evaluate the effects of subarachnoid morphine on recovery and lameness in sheep after stifle surgery.
- To identify potential adverse effects of intrathecal morphine in this surgical model.
Main Methods:
- Sheep received intrathecal injections of morphine (with preservatives), saline, or no injection (needle only).
- Recovery times (anesthesia to standing) and postoperative lameness scores were assessed.
- Videotaping and clinical observations were used to monitor sheep for adverse effects.
Main Results:
- No significant differences in time to standing or lameness scores were observed between morphine, saline, and control groups.
- Sheep receiving morphine exhibited hindlimb weakness, pruritus, and, in one case, extensor spasms.
- Adverse effects included licking/chewing of hindquarters and difficulty standing.
Conclusions:
- Subarachnoid morphine at 0.1 mg/kg provided no apparent benefit for stifle surgery recovery in sheep.
- Morphine administration was associated with detrimental side effects, including hindlimb weakness and pruritus.
- The use of subarachnoid morphine in this context is not recommended due to lack of efficacy and potential harm.