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Related Experiment Videos

Partial seizures associated with cisplatin administration: a case report

Y Fuse-Nagase1, K Suwa, Y Nagao

  • 1Department of Psychiatry, Aoyama Tokyo Metropolitan Officers' Hospital, Tokyo, Japan.

Clinical EEG (Electroencephalography)
|January 1, 1997
PubMed
Summary

Chemotherapy for tongue cancer can cause seizures. Carbamazepine and diazepam effectively controlled these seizures and abnormal EEG activity in a patient.

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Area of Science:

  • Oncology
  • Neurology
  • Pharmacology

Background:

  • Tongue cancer treatment often involves chemotherapy.
  • Cisplatin and pirarubicin are common chemotherapeutic agents.
  • Chemotherapy-induced seizures are a potential adverse effect.

Observation:

  • A 49-year-old male patient developed partial seizures after two courses of cisplatin and pirarubicin chemotherapy for tongue cancer.
  • Seizure manifestations included transient motor aphasia, tonic finger movement, and loss of consciousness.
  • Electroencephalogram (EEG) revealed frequent diffuse spike and slow wave discharges.

Findings:

  • Administration of carbamazepine and diazepam resulted in the cessation of seizures.
  • Post-treatment EEGs showed no recurrence of paroxysmal discharges.

Related Experiment Videos

  • The combination therapy was effective in managing chemotherapy-induced seizures.

    • Implications:

    • Carbamazepine and diazepam are effective in managing cisplatin and pirarubicin-induced seizures.
    • This case highlights the importance of monitoring for neurological adverse effects during chemotherapy.
    • Early intervention with anticonvulsant medication can prevent seizure recurrence and improve patient outcomes.