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Lipid profile in patients with microvascular angina
A D Tselepis1, M Elisaf, J Goudevenos
1Department of Chemistry, Medical School, University of Ioannina, Greece.
European Journal of Clinical Investigation
|December 1, 1996
Summary
Microvascular angina patients show lipid abnormalities similar to coronary artery disease (CAD) patients, but with higher high-density lipoprotein (HDL) cholesterol. These lipid profiles may influence microvascular angina pathophysiology and the lack of documented CAD.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Clinical Biochemistry
Background:
- Microvascular angina is a clinical syndrome characterized by chest pain, often attributed to coronary artery disease (CAD).
- Lipid and lipoprotein profiles are crucial determinants of cardiovascular risk and disease progression.
- Understanding lipid differences between microvascular angina and CAD is vital for accurate diagnosis and treatment.
Purpose of the Study:
- To compare lipid, lipoprotein, apolipoprotein levels, and low-density lipoprotein (LDL) oxidation susceptibility in microvascular angina patients versus CAD patients and healthy controls.
- To investigate the potential role of specific lipid parameters in the pathophysiology of microvascular angina.
- To explore the relationship between lipid profiles and the absence of angiographically documented CAD in microvascular angina patients.
Main Methods:
- Cross-sectional study comparing lipid profiles, including total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoproteins A-I and B, triglycerides, and lipoprotein (a) [Lp(a)], in three groups: microvascular angina, CAD, and controls.
- Assessment of the susceptibility of LDL to oxidation using sigmoidal curves and electrophoretic mobility.
- Statistical analysis to determine significant differences in measured parameters between the study groups.
Main Results:
- Microvascular angina patients exhibited significantly higher total cholesterol, LDL-cholesterol, apolipoprotein B, and Lp(a) levels compared to controls.
- HDL-cholesterol and apolipoprotein AI levels were similar to controls but significantly higher than in CAD patients.
- LDL oxidation susceptibility did not differ significantly among the groups; triglyceride levels were also comparable across groups.
Conclusions:
- Microvascular angina patients present with lipid abnormalities akin to CAD patients, notably elevated cholesterol and Lp(a).
- Higher HDL-cholesterol and apolipoprotein AI levels in microvascular angina patients may contribute to the absence of obstructive CAD.
- Abnormal cholesterol and Lp(a) levels are suggested to play a role in microvascular angina pathophysiology, potentially impacting endothelial function.