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Related Experiment Videos

Pharmacodynamic evaluation of codeine using tooth pulp evoked potentials

A Suri1, M L Kaltenbach, B L Grundy

  • 1Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville 32610, USA.

Journal of Clinical Pharmacology
|December 1, 1996
PubMed
Summary

Electrical tooth pulp stimulation provides a reliable method for assessing pain relief in human volunteers. This electroencephalographic (EEG) evoked potential (EP) technique efficiently measures analgesic drug efficacy, like codeine.

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Area of Science:

  • Neuroscience
  • Pain Research
  • Pharmacology

Background:

  • Assessing pain and analgesic efficacy in human volunteers is challenging, often requiring large sample sizes for statistical significance.
  • Electrical tooth pulp stimulation generates electroencephalographic (EEG) signals, forming somatosensory evoked potentials (EPs) that correlate with subjective pain reports.

Purpose of the Study:

  • To present an improved method for producing and recording tooth pulp evoked potentials (EPs).
  • To validate EPs as a reliable model for assessing analgesic activity in human subjects.
  • To evaluate the analgesic efficacy of codeine using the EP method.

Main Methods:

  • Developed an improved technique for generating and recording tooth pulp evoked potentials (EPs) in six healthy participants.

Related Experiment Videos

  • Utilized electroencephalography (EEG) to capture somatosensory evoked potentials following precisely controlled dental electrical stimuli.
  • Administered 60 mg of codeine orally to assess its effect on EP amplitudes and compared with visual analog pain ratings.

    • Main Results:

    • A reproducible EP response was obtained with only 16 EEG epochs, demonstrating the efficiency of the improved method.
    • Observed a significant decrease in evoked potential amplitudes after oral administration of codeine.
    • Results from EP amplitude changes were consistent with subjective pain ratings provided by the participants.

    Conclusions:

    • The improved tooth pulp evoked potential (EP) method offers an efficient and reliable model for pain assessment in human volunteers.
    • EPs provide an objective measure that correlates well with subjective pain perception, aiding in the evaluation of analgesic efficacy.
    • The study successfully demonstrated the utility of the EP technique in confirming the analgesic effect of codeine.