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Updated: Jul 21, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Actin dynamics in vivo
M D Welch1, A Mallavarapu, J Rosenblatt
1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA. welch@cgl.ucsf.edu
Abstract:
Actin dynamics in lamellipodia are driven by continuous cycles of actin polymerization, retrograde flow, and depolymerization. In the past year, advances have been made in identifying signaling pathways that regulate actin-filament uncapping and polymerization, in determining the role of myosin motor proteins in retrograde flow, and in evaluating the role of severing proteins in actin depolymerization. Both Listeria monocytogenes and Saccharomyces cerevisiae have emerged as powerful model organisms for studying actin dynamics in cells.
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