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Updated: Aug 17, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Role of the beta3-adrenoceptor in the control of leptin expression
1Département de Biochimie Médicale, Centre Médical Universitaire, Genève, Switzerland.
Abstract:
The inhibitory effect of beta-adrenoceptor agonists on leptin expression in brown and white adipose tissues is now well documented both in vivo and in vitro. It suggests the existence in vivo of a retroregulatory loop by which leptin inhibits its own expression via the sympathetic nervous system and the beta3-adrenoceptor. The hypothesis that the defect in beta3-adrenoceptor described in the adipose tissue of hereditary obese rodents can contribute to the resistance to leptin and to the increase in leptin expression observed in these animals is discussed.
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