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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

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Genetically engineered mice as animal models for NIDDM

R L Joshi¹, B Lamothe, D Bucchini

¹Institut Cochin de Génétique Moléculaire, INSERM U257, Paris, France.

|January 20, 1997

Summary

Genetically engineered mice with altered genes are crucial tools for studying complex polygenic diseases like non-insulin-dependent diabetes mellitus (NIDDM). Developing these animal models advances molecular understanding and research into NIDDM.

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Area of Science:

Genetics
Molecular Biology
Endocrinology

Background:

Complex polygenic diseases, such as non-insulin-dependent diabetes mellitus (NIDDM), require sophisticated models for molecular investigation.
Understanding the genetic underpinnings of NIDDM is crucial for developing effective treatments.

Purpose of the Study:

To explore the utility of genetically engineered animals in understanding polygenic diseases like NIDDM.
To investigate the creation of animal models with specific genetic alterations relevant to NIDDM.

Main Methods:

Utilizing transgenic and gene-targeting approaches in mice.
Altering the structure or expression of genes involved in insulin action and pancreatic beta-cell function.

Main Results:

Genetically engineered mice with defined genomic alterations have been successfully created.
These mice serve as foundational models for studying the molecular aspects of NIDDM.

Conclusions:

Genetically engineered mice are invaluable tools for advancing NIDDM research.
The development of multi-gene defect animal models is a significant step forward for understanding NIDDM.