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Characterization of lidocaine-specific T cells
M P Zanni1, D Mauri-Hellweg, C Brander
1Institute of Immunology and Allergology, Inselspital, Bern, Switzerland.
Journal of Immunology (Baltimore, Md. : 1950)
|February 1, 1997
Summary
Lidocaine allergy triggers a diverse T cell response, including CD4+ and CD8+ T cells, with some producing Th2-like cytokines (IL-5) and others Th1-like cytokines (IFN-gamma). This study highlights unique features of drug-specific T cell immunity.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Lidocaine allergy can manifest as contact dermatitis or systemic reactions.
- Understanding the cellular immune mechanisms underlying drug allergies is crucial for diagnosis and treatment.