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Interferon-omega suppresses hepatitis B surface antigen production in human hepatoma cell line
V Hajnická1, N Fuchsberger, H Liptáková
1Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Acta Virologica
|September 1, 1996
Abstract:
Biological activities of human interferon (IFN) omega are less well characterized than those of other type I human IFNs. We compared the ability of recombinant IFN-omega, IFN-alpha 2 and IFN-gamma to inhibit the production of viral hepatitis B surface antigen (HBsAg) in the human hepatoma cell line PLC/PRF/5. The results demonstrated that the capacity of IFN-omega to suppress the HBsAg synthesis was similar to that of IFN-alpha 2. The kinetics of the inhibitory effect of IFN-gamma differed from those of the two other IFNs.