[Glucose metabolism and blood flow studies in 2 cases with juvenile Parkinson's disease]

Cerebral glucose metabolism at resting state and blood flows during resting state, during finger-movement, and during finger-brushing stimulation were measured in two cases with juvenile Parkinson's disease(Narabayashi) with PET. Major symptom was rigidity and hypokinesia in both cases. Glucose metabolism was reduced in frontal cortex and increased at striatum. In one case with it-pallidotomy 1 year before glucose metabolism was more reduced over entire it-hemisphere including striatum than the right without any additional symptoms after the surgery. Blood flow was increased during 2 tasks and focal increase patterns were different from those in normal volunteers. Classical glucose metabolism and blood flow studies are still useful in this disorder.