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Survival in small intestinal adenocarcinoma
N Zar1, L Holmberg, E Wilander
1Department of Surgery, University Hospital, Uppsala, Sweden.
European Journal of Cancer (Oxford, England : 1990)
|November 1, 1996
Summary
Survival rates for small bowel adenocarcinoma are serious but improving. Women with jejunum/ileum tumors have better survival than men, and recent diagnoses show a more favorable prognosis.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Small bowel adenocarcinoma is rare but serious.
- Limited data exists on long-term survival trends.
Purpose of the Study:
- Investigate survival rates for duodenal and jejunum/ileum adenocarcinoma.
- Analyze survival by sex, age, and diagnosis year.
Main Methods:
- Retrospective analysis of 263 duodenal and 663 jejunum/ileum adenocarcinoma cases (1960-1988).
- Swedish Cancer Registry data utilized.
- Life-table and Cox proportional hazards analyses performed.
Main Results:
- Corrected 5-year survival: 39% (duodenum) vs. 46% (jejunum/ileum).
- Women with jejunum/ileum tumors had significantly better survival (P=0.0095).
- Survival correlated with age for duodenal tumors; improved prognosis noted in recent years.
Conclusions:
- Small bowel adenocarcinoma prognosis remains serious.
- Survival rates show a positive temporal trend.
- Prognosis varies by tumor site and sex.