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Fludrocortisone in the treatment of hypotensive disorders in the elderly
R M Hussain1, S J McIntosh, J Lawson
1Cardiovascular Investigation Unit, Royal victoria Infirmary, Newcastle upon Tyne.
Objective:
To evaluate tolerance of fludrocortisone in older patients with hypotensive disorders.
Design:
Prospective case series.
Setting:
Syncope clinic.
Patients:
64 Consecutive patients over 65 years (mean age 80 years) with one or more hypotensive disorders (orthostatic hypotension, vasodepressor carotid sinus syncope, and/or vasodepressor neurocardiogenic syncope.
Interventions:
Fludrocortisone in daily doses of 100 micrograms [corrected] (72%), 50 micrograms [corrected] (27%), and 200 micrograms [corrected] (one patient).
Main Outcome Measures:
Adverse events, treatment withdrawal.
Results:
During follow up 13 patients died of unrelated causes. Of the remainder 33% discontinued fludrocortisone at a mean of five months. Reasons for discontinuing treatment were hypertension, five; cardiac failure, four; depression, three; oedema, three; and unspecified, two. In those who continued treatment supine systolic and diastolic blood pressure did not differ significantly from baseline (follow up two to 21 months). Hypokalaemia developed in 24% at a mean of eight months; in no case was treatment withdrawn because of hypokalaemia.
Conclusion:
Fludrocortisone, even in low doses, is poorly tolerated in the long term in older patients with hypotensive disorders.