Related Experiment Video
Updated: Aug 12, 2026
07:06
Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Prophylaxis of rotavirus gastroenteritis using immunoglobulin
1Division of Immunology, Research Institute Miyagi Cancer Center, Japan.
Archives of Virology. Supplementum
|January 1, 1996
Summary
Passive immunization with immunoglobulin Y (IgY) from immunized hens and Rota colostrum from immunized cows effectively protected mice and infants against rotavirus diarrhea. Hyperimmune cow's milk shows promise as a functional food for preventing rotavirus infection.
Area of Science:
- Immunology
- Gastroenterology
- Pediatrics
Background:
- Human rotavirus (HRV) causes severe gastroenteritis, particularly in infants.
- Existing prevention methods are limited, necessitating novel therapeutic strategies.
- Animal models are crucial for studying HRV infection and evaluating potential interventions.
Purpose of the Study:
- To evaluate the efficacy of passive immunization using avian egg yolk immunoglobulin Y (IgY) and bovine colostrum against HRV infection.
- To assess the protective effect of Rota colostrum in a human infant clinical trial.
- To explore the potential of hyperimmune cow's milk as a functional food for rotavirus prevention.
Main Methods:
- BALB/c mice were orally inoculated with human rotavirus MO strain to model gastroenteritis.
- Passive protection was achieved using IgY from immunized hens and Rota colostrum from immunized cows.
- A clinical trial involved administering Rota colostrum to infants in a baby care center and comparing outcomes with a control group.
Main Results:
- IgY against homologous rotavirus strain conferred complete protection in mice.
- Rota colostrum completely protected suckling mice against rotavirus infection.
- In infants, Rota colostrum significantly reduced the incidence of rotavirus-associated diarrhea compared to controls.
Conclusions:
- Passive immunization with IgY and Rota colostrum is an effective and safe strategy for preventing rotavirus diarrhea.
- Rota colostrum demonstrates significant protective effects in both animal models and human infants.
- Hyperimmune cow's milk, produced after boosting immunized cows, is a promising candidate for a "physiologically functional food" in Japan.
Related Concept Videos
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...