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Basophil count in neonates is not suitable for atopy predictivity

M Calbi1, L Giacchetti, A Coppola

  • 1Department of Pediatrics, Villa Bianca Hospital, Naples, Italy.

Journal of Investigational Allergology & Clinical Immunology
|November 1, 1996
PubMed
Summary

Neonatal basophil counts were higher in infants who later developed atopy. However, elevated basophil counts at birth are not a reliable predictor for identifying infants at risk of developing atopic disorders.

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Area of Science:

  • Immunology
  • Allergy Research
  • Neonatal Health

Background:

  • Basophil granulocytes and their mediators play a role in allergic inflammation pathogenesis.
  • Understanding early indicators of atopic disorder development is crucial for timely intervention.

Purpose of the Study:

  • To evaluate basophil count, blood histamine, eosinophil count, and serum total IgE in newborns.
  • To determine if neonatal basophil counts can predict the development of atopic disorders up to 18 months of age.

Main Methods:

  • Measured basophil count, blood histamine, eosinophil count, and serum total IgE in 113 healthy newborns.
  • Prospectively followed 102 children for 18 months to track atopic disorder development.
  • Compared neonatal values between infants who developed atopy and those who did not.

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Main Results:

  • Infants who developed atopic disorders had higher neonatal basophil counts (p = 0.03).
  • No significant correlations were found between basophil counts and eosinophil counts, serum total IgE, or blood histamine.
  • The positive predictive value and sensitivity of neonatal basophil count for predicting allergy by 18 months were low (33% and 27%, respectively).

Conclusions:

  • Increased neonatal basophil count is not associated with family history of atopy.
  • Neonatal basophil count is not a reliable predictive marker for the development of atopic disorders within the first 18 months of life.