Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basophil count in neonates is not suitable for atopy predictivity

M Calbi1, L Giacchetti, A Coppola

  • 1Department of Pediatrics, Villa Bianca Hospital, Naples, Italy.

Journal of Investigational Allergology & Clinical Immunology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical experience with berotralstat in patients with hereditary angioedema: an Italian case series from the ITACA cohort.

European annals of allergy and clinical immunology·2026
Same author

Pulmonary ossification: a case report.

Frontiers in medicine·2025
Same author

Correction: Consensus‑driven protocol for transanal irrigation in patients with low anterior resection syndrome and functional constipation.

Techniques in coloproctology·2025
Same author

Consensus-driven protocol for transanal irrigation in patients with low anterior resection syndrome and functional constipation.

Techniques in coloproctology·2024
Same author

Influence of allergic status and nasal polyposis on long-term Benralizumab response in eosinophilic severe asthma.

La Clinica terapeutica·2023
Same author

Severe asthma and long-term Benralizumab effectiveness in real-life.

European review for medical and pharmacological sciences·2022

Neonatal basophil counts were higher in infants who later developed atopy. However, elevated basophil counts at birth are not a reliable predictor for identifying infants at risk of developing atopic disorders.

Area of Science:

  • Immunology
  • Allergy Research
  • Neonatal Health

Background:

  • Basophil granulocytes and their mediators play a role in allergic inflammation pathogenesis.
  • Understanding early indicators of atopic disorder development is crucial for timely intervention.

Purpose of the Study:

  • To evaluate basophil count, blood histamine, eosinophil count, and serum total IgE in newborns.
  • To determine if neonatal basophil counts can predict the development of atopic disorders up to 18 months of age.

Main Methods:

  • Measured basophil count, blood histamine, eosinophil count, and serum total IgE in 113 healthy newborns.
  • Prospectively followed 102 children for 18 months to track atopic disorder development.
  • Compared neonatal values between infants who developed atopy and those who did not.

Related Experiment Videos

Main Results:

  • Infants who developed atopic disorders had higher neonatal basophil counts (p = 0.03).
  • No significant correlations were found between basophil counts and eosinophil counts, serum total IgE, or blood histamine.
  • The positive predictive value and sensitivity of neonatal basophil count for predicting allergy by 18 months were low (33% and 27%, respectively).

Conclusions:

  • Increased neonatal basophil count is not associated with family history of atopy.
  • Neonatal basophil count is not a reliable predictive marker for the development of atopic disorders within the first 18 months of life.