Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Equivalent methods to analyse dynamic experiments in which the input function is noisy

R H Huesman1

  • 1Center for Functional Imaging, E. O Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA.

Physics in Medicine and Biology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of the Tachyon Time-of-Flight PET Camera.

IEEE transactions on nuclear science·2015
Same author

A detector response function design in pinhole SPECT including geometrical calibration.

Physics in medicine and biology·2013
Same author

Effects of temporal modelling on the statistical uncertainty of spatiotemporal distributions estimated directly from dynamic SPECT projections.

Physics in medicine and biology·2002
Same author

Theoretical study of lesion detectability of MAP reconstruction using computer observers.

IEEE transactions on medical imaging·2001
Same author

Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2001
Same author

Direct least-squares estimation of spatiotemporal distributions from dynamic SPECT projections using a spatial segmentation and temporal B-splines.

IEEE transactions on medical imaging·2000
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

This study compares two parameter estimation methods for dynamic experiments with noisy input functions. Both methods, despite different approaches, yield equivalent results for accurate model parameter estimation.

Area of Science:

  • Biomedical Engineering
  • Quantitative Imaging
  • Pharmacokinetics

Background:

  • Dynamic experiments often involve noisy input functions, complicating parameter estimation.
  • Uncertainties from input noise affect model-predicted values and the covariance matrix of residuals.
  • Accurate parameter estimation is crucial for interpreting dynamic experimental data, especially in fields like medical imaging.

Purpose of the Study:

  • To compare two distinct methods for parameter estimation in dynamic experiments with noisy input functions.
  • To demonstrate the equivalence of these two methods under specific conditions.
  • To provide a robust framework for analyzing dynamic emission tomography data.

Main Methods:

  • Method 1: Weighted least-squares using the inverse of the full covariance matrix of residuals (including input and output noise).

Related Experiment Videos

  • Method 2: Incorporating additional parameters for the input function and adding terms to the weighted sum of squares to account for input function differences.
  • Application to dynamic emission tomography studies of the heart, analyzing blood and tissue tracer concentrations.

    • Main Results:

    • The two methods, despite different theoretical underpinnings, were shown to be equivalent.
    • Both methods minimize the same criterion under matrix invertibility constraints.
    • This equivalence ensures the stability and reliability of parameter estimation in dynamic studies.

    Conclusions:

    • Parameter estimation in dynamic experiments with noisy inputs can be reliably performed using either of the compared methods.
    • The equivalence simplifies the choice of methodology, offering flexibility in analysis.
    • The findings are particularly relevant for improving quantitative accuracy in dynamic emission tomography.