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Updated: Jul 11, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
The Protein Information Resource (PIR) and the PIR-International Protein Sequence Database
D G George1, R J Dodson, J S Garavelli
1National Biomedical Research Foundation (NBRF), Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20007, USA. pirmail@nbrf.georgetown.edu
The Protein Information Resource (PIR) provides a vital, quality-controlled protein sequence database for computational biology and genomics research. This international collaboration ensures broad accessibility and integration with other major biological databases.
Area of Science:
- Bioinformatics
- Genomics
- Computational Biology
Background:
- The Protein Information Resource (PIR) originated from Margaret O. Dayhoff's early work in the 1960s.
- Since 1988, PIR has been maintained by PIR-International, a collaborative effort of macromolecular sequence data centers.
- PIR-International fosters international cooperation for developing scientific databases.
Purpose of the Study:
- To support research in computational biology and genomics.
- To compile a comprehensive, quality-controlled, and well-organized protein sequence information resource.
- To ensure wide distribution and accessibility of protein sequence data.
Main Methods:
- Compilation of protein sequence data.
- Quality control of sequence information.
- International collaboration among data collection centers.
Main Results:
- Creation of a comprehensive protein sequence database.
- Wide distribution of the database via multiple platforms (WWW, FTP, E-mail, CD-ROM, magnetic media).
- Integration of PIR data into other major databases like SWISS-PROT and NCBI's Entrez system.
Conclusions:
- PIR serves as a foundational resource for bioinformatics and genomics.
- International collaboration is key to maintaining and distributing valuable scientific databases.
- The resource's accessibility and integration facilitate broader scientific discovery.
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