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Related Experiment Videos

The Radiation Hybrid Database

P Rodriguez-Tomé1, P Lijnzaad

  • 1EMBL Outstation, Hinxton-The European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. tome@ebi.ac.uk

Nucleic Acids Research
|January 1, 1997
PubMed
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RHdb, a public database, provides radiation hybrid data for creating genetic maps. This data aids in ordering genetic markers, including non-polymorphic ones, for improved mapping resolution.

Area of Science:

  • Bioinformatics
  • Genetics
  • Genomics

Background:

  • The European Bioinformatics Institute (EBI) has managed RHdb since 1995.
  • RHdb is a public database for radiation hybrid (RH) data.
  • RH data is crucial for generating alternative genetic maps.

Purpose of the Study:

  • To highlight the utility of RHdb for genetic mapping.
  • To explain the advantages of using RH data for marker ordering.

Main Methods:

  • Maintenance of a public database (RHdb) for radiation hybrid data.
  • Utilizing radiation hybrid data for genetic map generation.

Main Results:

  • RH data enables the inclusion of non-polymorphic markers in genetic maps.

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  • RH data effectively orders unresolved clusters of polymorphic Sequence Tagged Sites (STSs).

    • Conclusions:

    • RHdb is a valuable resource for genetic mapping.
    • Radiation hybrid mapping offers a powerful approach for constructing high-resolution genetic maps.