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The Signal Recognition Particle Database (SRPDB)

C Zwieb1, N Larsen

  • 1Department of Molecular Biology, The University of Texas Health Science Center, PO Box 2003, Tyler, TX 75710, USA. zwieb@jason.uthct.edu

Nucleic Acids Research
|January 1, 1997
PubMed
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The Signal Recognition Particle Database (SRPDB) now includes more RNA and protein sequences for studying the SRP pathway. This update enhances resources for understanding protein targeting and translocation.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • The Signal Recognition Particle (SRP) pathway is crucial for targeting proteins to cellular membranes.
  • Comprehensive sequence and structural data are essential for studying SRP evolution and function.

Purpose of the Study:

  • To update and expand the Signal Recognition Particle Database (SRPDB) with new sequence data.
  • To provide researchers with enhanced resources for analyzing SRP RNA and protein sequences.

Main Methods:

  • Curated collection and alignment of SRP RNA and SRP protein sequences.
  • Phylogenetic ordering and annotation of sequence data.
  • Inclusion of structural data and search tools.

Main Results:

Related Experiment Videos

  • The SRPDB now contains 96 SRP RNA sequences and 39 SRP protein sequences (SRP9, SRP14, SRP19, SRP21, SRP54, SRP68, SRP72).
  • New additions include 3 SRP RNA and 11 SRP protein sequences.
  • Downloadable resources now feature SRP RNA secondary structure diagrams and a 3D model of human SRP RNA.

Conclusions:

  • The updated SRPDB provides a more comprehensive resource for researchers studying the SRP pathway.
  • Enhanced data facilitates deeper investigations into SRP evolution, structure, and function.
  • Availability of structural models and search motifs aids in experimental design and data analysis.