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Novel developments with the PRINTS protein fingerprint database

T K Attwood1, M E Beck, A J Bleasby

  • 1Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WCIE 6BT, UK. attwood@bsm.bioc.ucl.ac.uk

Nucleic Acids Research
|January 1, 1997
PubMed
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The PRINTS database now contains 600 protein family fingerprints, enhancing protein identification. This resource uses conserved motifs for reliable family membership determination, complementing existing tools.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Protein Science

Background:

  • The PRINTS database provides protein family "fingerprints" for diagnostics.
  • Fingerprints use conserved motifs in sequence alignments for family signatures.
  • This approach offers improved reliability compared to simple patterns.

Purpose of the Study:

  • To report on the progress and expansion of the PRINTS database.
  • To highlight the enhanced diagnostic capabilities of protein family fingerprints.
  • To introduce new features for database accessibility and manipulation.

Main Methods:

  • Development and curation of protein family "fingerprints".
  • Expansion of the PRINTS database to include approximately 3000 motifs.

Related Experiment Videos

  • Integration of a novel color alignment editor (CINEMA) for web-based visualization.

    • Main Results:

    • The PRINTS database has grown to 600 fingerprints, a 50% increase in one year.
    • Version 13.0 encodes around 3000 motifs.
    • A new web interface with CINEMA allows interactive manipulation of alignments online.

    Conclusions:

    • The PRINTS database is a valuable and expanding resource for protein family identification.
    • The integration of CINEMA enhances usability and accessibility of the database.
    • Protein family fingerprints offer a powerful method for reliable sequence analysis.