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The ribonuclease P database

J W Brown1

  • 1Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA. jwbrown@mbio.ncsu.edu

Nucleic Acids Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Ribonuclease P, a crucial enzyme for tRNA maturation, is a ribozyme in bacteria. The Ribonuclease P Database offers a comprehensive resource for its sequences and structural information online.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Ribonuclease P (RNase P) is essential for processing transfer RNA (tRNA) precursors.
  • In bacteria, the RNA component of RNase P exhibits catalytic activity, classifying it as a ribozyme.
  • Understanding RNase P function is vital for tRNA biogenesis research.

Purpose of the Study:

  • To provide a centralized repository for Ribonuclease P (RNase P) related data.
  • To facilitate research on the structure, function, and evolution of RNase P.
  • To make RNase P sequences, alignments, and structural models accessible to the scientific community.

Main Methods:

  • Compilation of known Ribonuclease P (RNase P) sequences from various bacterial species.
  • Generation of multiple sequence alignments for comparative analysis.

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  • Inclusion of secondary structure predictions and available three-dimensional models.
  • Development of a web-accessible database for data retrieval.

    • Main Results:

    • The Ribonuclease P Database serves as a comprehensive collection of RNase P sequences and associated data.
    • Detailed alignments and structural information are provided for numerous RNase P RNA subunits.
    • The database includes accessory information relevant to RNase P research.
    • Accessibility via the World Wide Web enables global access to these resources.

    Conclusions:

    • The Ribonuclease P Database is a valuable resource for researchers studying tRNA processing and ribozymes.
    • Centralized data facilitates comparative genomics and structural biology of RNase P.
    • Web accessibility promotes wider scientific collaboration and discovery in the field of RNA catalysis.