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Related Experiment Videos

Histone and histone fold sequences and structures: a database

A D Baxevanis1, D Landsman

  • 1Genome Technology Branch, National Center for Human Genome Research, National Institutes of Health, Bethesda, MD 20892, USA.

Nucleic Acids Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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A new database of aligned histone protein sequences is now available, integrating homology search results and known histone fold proteins. This resource aids researchers by providing sequence alignments and conflict information for over 1000 proteins.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Structural Biology

Background:

  • Histones are crucial proteins involved in DNA packaging and gene regulation.
  • Understanding histone protein sequences and structures is fundamental to molecular biology.
  • Existing sequence databases may have inconsistencies or lack comprehensive alignment data.

Purpose of the Study:

  • To create a centralized, aligned database of histone protein sequences.
  • To incorporate proteins with the histone fold motif and known histone structures.
  • To provide valuable resources for researchers studying histones and their functions.

Main Methods:

  • Conducted homology searches across major public sequence databases.
  • Collected sequences of proteins containing the histone fold motif.

Related Experiment Videos

  • Integrated structural data for known histone and histone fold proteins.
  • Developed a database with over 1000 protein sequences and multiple sequence alignments.

    • Main Results:

    • A comprehensive database of aligned histone protein sequences has been established.
    • The database includes information on sequence entry conflicts across different sources.
    • Links to the National Center for Biotechnology Information (NCBI) Entrez system are provided for integrated data retrieval.
    • The database contains over 1000 protein sequences and associated alignments.

    Conclusions:

    • The developed histone protein sequence database serves as a valuable resource for the scientific community.
    • It facilitates research by offering aligned sequences, structural information, and data consistency checks.
    • The database is accessible online, promoting wider use and discovery in histone research.