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Related Experiment Videos

Negative selection in the thymus includes semimature T cells

H Kishimoto1, J Sprent

  • 1Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037, USA.

The Journal of Experimental Medicine
|January 20, 1997
PubMed
Summary
This summary is machine-generated.

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Medullary T cells are not fully mature and can still be tolerized. A semimature subset of medullary T cells is susceptible to tolerance induction, unlike fully mature cells.

Area of Science:

  • Immunology
  • T cell development

Background:

  • The thymic medulla is crucial for T cell negative selection and self-tolerance.
  • Mature medullary T cells are generally considered resistant to tolerance induction.

Purpose of the Study:

  • To investigate the tolerance susceptibility of medullary T cells.
  • To resolve the paradox of tolerance induction in the thymic medulla.

Main Methods:

  • Analysis of medullary T cell subsets based on HSA expression (HSAlo and HSAhi).
  • Assessment of tolerance induction in these subsets.

Main Results:

  • Medullary T cells comprise two subsets: HSAlo (mature, resistant) and HSAhi (semimature, susceptible).
  • Semimature medullary T cells remain sensitive to tolerance induction.

Related Experiment Videos

  • Tolerance induction in semimature cells can be Fas-dependent or Fas-independent.

    • Conclusions:

    • Differentiated T cells in the medulla retain sensitivity to tolerance induction briefly before becoming resistant.
    • The semimature medullary T cell subset offers a window for tolerance induction.
    • Distinct pathways (Fas-dependent/independent) mediate tolerance induction in semimature T cells.