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Amphetamines, growth hormone and narcolepsy

J D Parkes, A G Debono, P Jenner

    British Journal of Clinical Pharmacology
    |June 1, 1977
    PubMed
    Summary
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    Amphetamine isomers did not increase growth hormone in narcoleptics, unlike in healthy individuals. Higher amphetamine doses or Sinemet showed limited growth hormone response in narcolepsy patients.

    Area of Science:

    • Pharmacology
    • Neuroendocrinology

    Background:

    • Narcolepsy is a sleep disorder potentially linked to neurotransmitter dysfunction.
    • Amphetamines are known stimulants affecting various physiological processes.
    • Growth hormone release is regulated by complex neuroendocrine pathways.

    Purpose of the Study:

    • To investigate the effect of amphetamine isomers on plasma growth hormone levels in narcoleptic and normal subjects.
    • To compare the efficacy of different amphetamine doses and Sinemet in altering growth hormone concentrations in narcolepsy.

    Main Methods:

    • Administered single oral doses of (+)-amphetamine (20 mg), (-)-amphetamine (20 mg), and amphetamine (30 mg) to subjects.
    • Measured plasma amphetamine and growth hormone levels over time.
    • Administered Levodopa/carbidopa (Sinemet) and measured growth hormone response.

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    Main Results:

    • (+)- and (-)-amphetamine (20 mg) increased growth hormone in normal subjects but not in narcoleptics.
    • Plasma amphetamine levels and time curves were similar for both isomers and subject groups.
    • A higher amphetamine dose (30 mg) elicited a growth hormone increase in only two of six narcoleptics.
    • Sinemet increased growth hormone in normal subjects, with a diminished response observed in narcoleptics.

    Conclusions:

    • Narcoleptic subjects exhibit an impaired growth hormone response to amphetamine isomers compared to healthy individuals.
    • The neuroendocrine response to dopaminergic agents like amphetamine and Sinemet differs between narcoleptic and normal populations.
    • These findings suggest a potential disruption in the growth hormone regulatory pathways in narcolepsy.