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Related Experiment Videos

Blood-CSF barrier integrity in multiple sclerosis

R Liebsch1, M E Kornhuber, D Dietl

  • 1Department of Neurology, Technische Universität München, Germany.

Acta Neurologica Scandinavica
|December 1, 1996
PubMed
Summary
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Increased CSF/serum albumin quotient (QAlb) in multiple sclerosis (MS) patients may indicate active spinal lesions. This finding relates to blood-CSF barrier dysfunction and aids in diagnosing MS activity.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Biomarkers

Background:

  • An elevated cerebrospinal fluid (CSF)/serum albumin quotient (QAlb) is observed in approximately 20% of multiple sclerosis (MS) patients.
  • The underlying cause of this blood-CSF barrier dysfunction in MS remains unclear.

Purpose of the Study:

  • To investigate the correlation between QAlb levels and active central nervous system (CNS) lesions in MS patients.
  • To determine if QAlb can serve as a biomarker for lesion location and activity in MS.

Main Methods:

  • QAlb values were measured in 48 relapsing MS patients and compared to 20 non-relapsing MS patients.
  • Active CNS lesions were assessed using gadolinium-enhanced MRI.

Main Results:

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  • Mean QAlb values were significantly higher in MS patients with spinal cord lesions compared to controls (p < 0.005).
  • Elevated QAlb was also observed in patients with supratentorial lesions (p < 0.05) and infratentorial lesions.
  • QAlb levels in patients with spinal lesions tended to decrease over time post-relapse.

    • Conclusions:

    • Increased QAlb values in MS patients suggest the presence of active spinal or, less commonly, infratentorial lesions.
    • Findings align with current understanding of fluid dynamics in the CNS.
    • Elevated QAlb may serve as a clinical indicator of MS lesion activity.