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Related Experiment Videos

Leuko-araiosis and stroke: a case-control study

A Awada1, M F Omojola

  • 1Department of Medicine, King Fahad National Guard Hospital, Riyadh, Saudi Arabia.

Acta Neurologica Scandinavica
|December 1, 1996
PubMed
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Leuko-araiosis (LA) in Saudi patients is linked to older age, brain atrophy, and hypertension. It is most commonly associated with lacunar infarcts, a type of stroke.

Area of Science:

  • Neurology
  • Radiology
  • Epidemiology

Background:

  • Leuko-araiosis (LA) is a common finding on neuroimaging, often associated with cerebrovascular risk factors.
  • Previous studies on LA risk factors have primarily focused on Western populations.

Purpose of the Study:

  • To investigate the risk factors and stroke types associated with leuko-araiosis (LA) in a Saudi patient cohort.
  • To compare the prevalence of LA and its associated factors in Saudi stroke patients.

Main Methods:

  • A case-control study involving 398 Saudi stroke patients over a 6-year period.
  • Cranial computed tomography (CT) was used to assess the presence or absence of LA.
  • Statistical analysis, including odds ratios (OR) and 95% confidence intervals (CI), was employed to determine associations.

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Main Results:

  • Leuko-araiosis (LA) was more prevalent in older patients (mean age 67.8 years) and increased with age.
  • Significant associations were found between LA and generalized brain atrophy (OR 2.7), lacunar infarcts (OR 3.4), and systemic hypertension (OR 2.15).
  • LA was not significantly associated with cerebral hemorrhage or larger infarcts.

Conclusions:

  • Leuko-araiosis (LA) in Saudi patients is primarily associated with advanced age, cerebral atrophy, systemic hypertension, and lacunar infarcts.
  • These findings highlight specific risk profiles for LA in the Saudi population, differing from some Western cohorts.