Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural evidence for membrane lipid changes in human cataract

J Feher1, S M Recupero, S Abdolrahimzadeh

  • 1Institute of Ophthalmology, Università di Roma La Sapienza, Italy.

Acta Ophthalmologica Scandinavica
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nab-Paclitaxel related cystoid macular edema.

La Clinica terapeutica·2022
Same author

The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis.

Actas urologicas espanolas·2020
Same author

Eye on the Gut: Irritable Eye Syndrome

La Clinica terapeutica·2019
Same author

Evaluation of Agreement between HRT III and iVue OCT in Glaucoma and Ocular Hypertension Patients.

Journal of ophthalmology·2016
Same author

Intracameral epinephrine without the addition of intracameral lidocaine in the management of tamsulosin associated intraoperative floppy iris syndrome.

La Clinica terapeutica·2015
Same author

Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation.

Folia morphologica·2015
Same journal

Expression of interleukin-6, tumour necrosis factor-alpha and nitric oxides during episodes of ocular toxoplasmosis in an HIV patient.

Acta ophthalmologica Scandinavica·2007
Same journal

Varicella chorioretinitis.

Acta ophthalmologica Scandinavica·2007
Same journal

Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related ophthalmological variables.

Acta ophthalmologica Scandinavica·2007
Same journal

Solving the enigma of exfoliation glaucoma: a breakthrough in glaucoma research.

Acta ophthalmologica Scandinavica·2007
Same journal

Incidence and prevalence of pseudoexfoliations and open-angle glaucoma in northern Sweden: II. Results after 21 years of follow-up.

Acta ophthalmologica Scandinavica·2007
Same journal

Incidence and prevalence of pseudoexfoliation and open-angle glaucoma in northern Sweden: I. Baseline report.

Acta ophthalmologica Scandinavica·2007
See all related articles

Lipid changes in human lenses show increased density and altered structures during early cataract formation. Advanced cataracts involve the disappearance of membrane lipids, indicating a key role in cataractogenesis.

Area of Science:

  • Ophthalmology
  • Biochemistry
  • Cell Biology

Background:

  • Cataractogenesis involves changes in the lens's optical properties.
  • Lipid composition and organization are critical for cell membrane integrity.
  • Understanding lens lipid alterations may elucidate cataract development mechanisms.

Purpose of the Study:

  • To investigate intramembrane lipid changes during human cataractogenesis.
  • To correlate lipid alterations with varying degrees of lens opacity.

Main Methods:

  • Histochemical analysis using polarization microscopy on frozen, formaldehyde-fixed human lenses.
  • Quantification of light retardation in cell membrane lipids across transparent and cataractous regions.

Main Results:

Related Experiment Videos

  • Transparent lenses showed cell membrane lipids with 8.0 nm light retardation.
  • Early cataracts exhibited increased membrane lipid retardation (23.3 nm) and formation of fusiform (37.7 nm) and globular (48.5 nm) lipid structures.
  • Advanced cortical cataracts were characterized by the absence of membrane lipids.

Conclusions:

  • Intramembrane lipid alterations are demonstrably associated with cataractogenesis.
  • Progressive lipid density changes and structural modifications occur during cataract development.
  • The disappearance of membrane lipids correlates with confluent cortical cataracts.