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Cytokines and their effects on maturation, differentiation and migration of dendritic cells
1Department of Dermatology, University of Mainz, Germany.
Archives of Dermatological Research
|December 1, 1996
Abstract:
In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-alpha to direct the development of individual DC subpopulations.