Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obesity and metabolic efficiency

A Astrup1

  • 1Research Department of Human Nutrition, Royal Veterinary & Agricultural University, Frederiksberg C, Copenhagen, Denmark.

Ciba Foundation Symposium
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.

Nature metabolism·2024
Same author

Does the concept of "ultra-processed foods" help inform dietary guidelines, beyond conventional classification systems? NO.

The American journal of clinical nutrition·2022
Same author

Sustainable and personalized nutrition: From earth health to public health.

European journal of internal medicine·2021
Same author

The association between vitamin D receptor polymorphisms and tissue-specific insulin resistance in human obesity.

International journal of obesity (2005)·2021
Same author

Influence of type of dairy matrix micro- and macrostructure on in vitro lipid digestion.

Food & function·2020
Same author

The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study.

Nutrients·2020
Same journal

Precision agriculture: spatial and temporal variability of environmental quality. General reflections.

Ciba Foundation symposium·1997
Same journal

Uncertainty in hydrogeological modelling.

Ciba Foundation symposium·1997
Same journal

Optimal mapping of site-specific multivariate soil properties.

Ciba Foundation symposium·1997
Same journal

Modelling for precision weed management.

Ciba Foundation symposium·1997
Same journal

GIS support for precision agriculture: problems and possibilities.

Ciba Foundation symposium·1997
Same journal

Spatial sampling.

Ciba Foundation symposium·1997
See all related articles

Obesity involves genetic predisposition and environmental factors affecting energy balance. Key factors include overeating triggers, reduced resting metabolic rate, and physical activity levels contributing to weight gain.

Area of Science:

  • Metabolic research
  • Obesity research
  • Genetics

Background:

  • Obesity is influenced by genetic predisposition interacting with environmental factors.
  • Energy balance regulation is crucial in weight gain and obesity development.
  • Susceptible individuals may experience overeating due to dietary fat, portion sizes, and meal frequency.

Purpose of the Study:

  • To explore the multifaceted mechanisms underlying obesity.
  • To investigate the roles of metabolic efficiency, energy expenditure, and environmental triggers in obesity.
  • To understand the genetic and physiological factors contributing to weight gain.

Main Methods:

  • Analysis of resting metabolic rate and total energy expenditure.
  • Assessment of thermic effect of food (TEF).

Related Experiment Videos

  • Examination of genetic influences on metabolic efficiency during overfeeding.
  • Investigation of fat and carbohydrate partitioning and hormonal responses.

    • Main Results:

    • Low resting metabolic rate and physical activity amplify energy expenditure reduction.
    • Thermic effect of food is not a risk factor for weight gain.
    • Genetically determined metabolic efficiency during overfeeding contributes to fat gain.
    • Heterogeneity in obesity suggests diverse mechanisms involving fat partitioning and hormonal regulation.

    Conclusions:

    • Obesity results from a complex interplay of genetic predisposition and environmental influences on energy balance.
    • Reduced metabolic efficiency and physical activity are significant contributors to weight gain.
    • Further research into fat partitioning and hormonal responses is needed to understand obesity's diverse mechanisms.