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Carbon disulphide. IV. Cardiovascular function in workers in the viscose industry
1Institute and Out-patient Clinic for Occupational, University of Erlangen-Nuremberg, Germany.
International Archives of Occupational and Environmental Health
|January 1, 1996
Summary
Occupational exposure to carbon disulfide (CS2) did not increase coronary heart disease risk. However, CS2 may negatively impact heart muscle function, though without apparent clinical significance in workers.
Area of Science:
- Occupational Medicine
- Cardiology
- Toxicology
Background:
- Occupational exposure to carbon disulfide (CS2) is a concern in industrial settings.
- Previous research suggests potential cardiovascular risks associated with CS2 exposure.
- Understanding the cardiac effects of CS2 at current occupational limits is crucial.
Purpose of the Study:
- To investigate the prevalence of coronary heart disease (CHD) in workers exposed to CS2.
- To assess for unusual cardiological findings in CS2-exposed individuals.
- To evaluate cardiac function in relation to CS2 exposure levels.
Main Methods:
- Cross-sectional study comparing 247 CS2-exposed men with 222 controls.
- Exposure assessment via personal air monitoring and biological monitoring.
- Cardiovascular assessment included physical exams, arterial ultrasound, ECG, and echocardiography.
Main Results:
- No increased prevalence of CHD or arteriosclerotic findings in CS2-exposed workers.
- Echocardiography revealed statistically significant increases in left atrium and left ventricle diameters (1-2 mm) in exposed subjects.
- Left ventricular telesystolic diameter correlated with internal CS2 exposure; fractional shortening showed a negative trend.
Conclusions:
- Findings suggest a potential negative inotropic effect of CS2 in humans.
- This effect did not appear to have clinical relevance at the exposure levels studied.
- Further research may be needed to fully elucidate the cardiac impact of CS2.