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HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its

V G Cabana1, J R Lukens, K S Rice

  • 1Department of Pathology, University of Chicago, IL 60637, USA.

Journal of Lipid Research
|December 1, 1996
PubMed
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High-density lipoprotein (HDL) levels drop during the acute phase response (APR). Research in rabbits, baboons, and mice suggests hypertriglyceridemia and serum amyloid A (SAA) influence HDL decline.

Area of Science:

  • Lipid Metabolism
  • Cardiovascular Research
  • Immunology

Background:

  • High-density lipoprotein (HDL) levels characteristically decrease during the acute phase response (APR).
  • Understanding the mechanisms behind HDL reduction during APR is crucial for cardiovascular health.
  • Species-specific variations in HDL response to APR warrant investigation.

Purpose of the Study:

  • To investigate the factors influencing high-density lipoprotein (HDL) levels during the acute phase response (APR) using animal models.
  • To elucidate the role of hypertriglyceridemia, apolipoprotein A-I (apoA-I) dynamics, and serum amyloid A (SAA) in HDL reduction.

Main Methods:

  • Utilized acute phase response (APR) models in rabbits, baboons, and mice.
  • Analyzed changes in HDL cholesterol, triglyceride enrichment, and apolipoprotein A-I (apoA-I) levels.

Related Experiment Videos

  • Characterized SAA-rich HDL particles using non-denaturing gradient electrophoresis and electron microscopy.

    • Main Results:

    • Rabbits and baboons exhibited hypertriglyceridemia, significant HDL triglyceride enrichment, decreased HDL-cholesterol, and reduced apoA-I, with apoA-I dissociation from particles.
    • SAA-rich HDL particles in rabbits were large and triglyceride-enriched, with a high surface-to-core ratio and protein proportion.
    • Mice showed no hypertriglyceridemia or HDL-cholesterol decrease, but did exhibit reduced apoA-I and SAA-enriched HDL particles.

    Conclusions:

    • Hypertriglyceridemia, HDL triglyceride enrichment, and apoA-I dissociation, potentially mediated by SAA, are key factors in HDL decline during APR.
    • Species differences in HDL response during APR may be linked to variations in triglyceride metabolism.
    • Further research is needed to confirm the role of triglyceride metabolism in interspecies HDL response variations during APR.