Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HDL content and composition in acute phase response in three species: triglyceride enrichment of HDL a factor in its

V G Cabana1, J R Lukens, K S Rice

  • 1Department of Pathology, University of Chicago, IL 60637, USA.

Journal of Lipid Research
|December 1, 1996
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural killer T cells in lipoprotein metabolism and atherosclerosis.

Thrombosis and haemostasis·2011
Same author

HDL apolipoprotein-related peptides in the treatment of atherosclerosis and other inflammatory disorders.

Current pharmaceutical design·2010
Same author

In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice.

Biochemistry·2001
Same author

Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses.

Neurochemistry international·2001
Same author

Plant microtubule-associated proteins: the HEAT is off in temperature-sensitive mor1.

Trends in plant science·2001
Same author

The first human monoclonal antibody to oxidized LDL.

Arteriosclerosis, thrombosis, and vascular biology·2001

High-density lipoprotein (HDL) levels drop during the acute phase response (APR). Research in rabbits, baboons, and mice suggests hypertriglyceridemia and serum amyloid A (SAA) influence HDL decline.

Area of Science:

  • Lipid Metabolism
  • Cardiovascular Research
  • Immunology

Background:

  • High-density lipoprotein (HDL) levels characteristically decrease during the acute phase response (APR).
  • Understanding the mechanisms behind HDL reduction during APR is crucial for cardiovascular health.
  • Species-specific variations in HDL response to APR warrant investigation.

Purpose of the Study:

  • To investigate the factors influencing high-density lipoprotein (HDL) levels during the acute phase response (APR) using animal models.
  • To elucidate the role of hypertriglyceridemia, apolipoprotein A-I (apoA-I) dynamics, and serum amyloid A (SAA) in HDL reduction.

Main Methods:

  • Utilized acute phase response (APR) models in rabbits, baboons, and mice.
  • Analyzed changes in HDL cholesterol, triglyceride enrichment, and apolipoprotein A-I (apoA-I) levels.

Related Experiment Videos

  • Characterized SAA-rich HDL particles using non-denaturing gradient electrophoresis and electron microscopy.

    • Main Results:

    • Rabbits and baboons exhibited hypertriglyceridemia, significant HDL triglyceride enrichment, decreased HDL-cholesterol, and reduced apoA-I, with apoA-I dissociation from particles.
    • SAA-rich HDL particles in rabbits were large and triglyceride-enriched, with a high surface-to-core ratio and protein proportion.
    • Mice showed no hypertriglyceridemia or HDL-cholesterol decrease, but did exhibit reduced apoA-I and SAA-enriched HDL particles.

    Conclusions:

    • Hypertriglyceridemia, HDL triglyceride enrichment, and apoA-I dissociation, potentially mediated by SAA, are key factors in HDL decline during APR.
    • Species differences in HDL response during APR may be linked to variations in triglyceride metabolism.
    • Further research is needed to confirm the role of triglyceride metabolism in interspecies HDL response variations during APR.