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Related Experiment Videos

Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop)

M S George1, T A Ketter, P I Parekh

  • 1Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. georgem@musc.edu

The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1997
PubMed
Summary

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Depression is linked to abnormal brain activity, specifically blunted activation in the anterior cingulate during cognitive tasks. Mood-disordered subjects showed altered brain responses compared to healthy controls, supporting theories of depression neuroanatomy.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Functional neuroimaging reveals altered anterior cingulate cortex (ACC) activity in depression.
  • The ACC is typically activated during interference tasks in healthy individuals.

Purpose of the Study:

  • To investigate cingulate activation differences between mood-disordered subjects and healthy controls during a Stroop interference task.
  • To explore if mood disorder is associated with blunted cingulate activation or altered prefrontal cortex activity.

Main Methods:

  • Utilized functional neuroimaging to compare brain activity in 11 mood-disordered subjects and 11 healthy controls.
  • Administered a standard Stroop interference task and a modified version with sadness-laden words.

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Main Results:

  • Healthy subjects showed left cingulate activation during the standard Stroop task.
  • Mood-disordered subjects exhibited minimal right anterior cingulate activation.
  • Increased activity was observed in the left dorsolateral prefrontal cortex and visual cortex in mood-disordered subjects.

Conclusions:

  • Findings support theories of blunted limbic and paralimbic activation in depression.
  • The study highlights abnormal cingulate activity and altered functional neuroanatomy in the depressed brain.