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Angiographic abnormalities of experimental autoimmune uveoretinitis
L J Howe1, M R Stanford, R Whiston
1Department of Ophthalmology, United Medical School, St. Thomas' Hospital, London, UK.
Current Eye Research
|December 1, 1996
Summary
Experimental autoimmune uveoretinitis (EAU) in rats showed retinal vascular leakage using indocyanine green (ICG) and fluorescein angiography. This model is suitable for studying inflammatory eye diseases with ICG angiography.
Area of Science:
- Ophthalmology
- Immunology
- Medical Imaging
Background:
- Experimental autoimmune uveoretinitis (EAU) is a key animal model for human inflammatory eye diseases.
- Indocyanine green (ICG) and fluorescein are vital contrast agents for imaging retinal and choroidal vasculature.
Purpose of the Study:
- To evaluate retinal and choroidal vascular abnormalities in a rat model of EAU.
- To assess the utility of ICG angiography in conjunction with fluorescein for studying inflammatory eye conditions.
Main Methods:
- Twenty-six rats were induced with EAU using bovine retinal S-antigen and adjuvant.
- Fluorescein and ICG angiograms were performed using a scanning laser ophthalmoscope during disease progression.
Main Results:
- Rats receiving Bordetella pertussis showed more severe EAU, primarily affecting choroidal disease, but without large choroidal vessel leakage.
- Significant leakage of ICG from retinal vessels was observed, correlating with disease activity.
- Retinal pigment epithelial lesions showed distinct patterns on ICG and fluorescein angiography.
Conclusions:
- The study successfully demonstrated vascular abnormalities in the EAU rat model using ICG and fluorescein angiography.
- This model shows promise for investigating ICG angiographic findings in human inflammatory eye diseases.