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Infectious agents associated with myopathies

S R Ytterberg1

  • 1Department of Medicine, Department of Veterans Affairs Medical Center, Minneapolis, MN, USA.

Current Opinion in Rheumatology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

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Infectious agents can cause acute or chronic myopathy. While retroviruses like HIV induce immune-mediated myositis, the role of enteroviruses in human myositis remains unclear.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Idiopathic inflammatory myopathies (IIM) are often investigated for infectious causes.
  • Retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Leukemia-Lymphoma Virus type I (HTLV-I), are implicated in IIM.
  • These viruses are thought to trigger immune responses leading to myositis rather than directly infecting muscle.

Purpose of the Study:

  • To review the role of infectious agents in causing myopathy.
  • To explore the potential link between enteroviruses and idiopathic inflammatory myopathy.
  • To discuss acute myositis conditions like pyomyositis and rhabdomyolysis.

Main Methods:

  • Literature review of studies on infectious agents and myopathies.

Related Experiment Videos

  • Analysis of research on retroviral and enteroviral involvement in myositis.
  • Examination of clinical presentations of acute infectious myopathies.

    • Main Results:

    • Retroviruses (HIV, HTLV-I) are recognized causes of immune-mediated myositis in IIM.
    • The association between enteroviruses and human myositis is less clearly defined.
    • Pyomyositis and rhabdomyolysis are infectious causes of acute myopathy, increasingly seen in non-tropical regions.

    Conclusions:

    • Infectious agents are significant contributors to both chronic and acute myopathies.
    • Further research is needed to clarify the role of enteroviruses in human myositis.
    • Increased recognition of pyomyositis and rhabdomyolysis highlights the importance of infectious etiologies in acute muscle disease.