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Baroreflex sensitivity during operant blood pressure conditioning

D S Goldstein, A H Harris, J V Brady

    Biofeedback and Self-Regulation
    |June 1, 1977
    PubMed
    Summary
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    Operant conditioning to elevate blood pressure in baboons altered baroreflex sensitivity. While overall sensitivity increased post-training, it significantly decreased during conditioning sessions, suggesting its role in blood pressure regulation.

    Area of Science:

    • Physiology
    • Behavioral Neuroscience

    Background:

    • Baroreflex sensitivity is crucial for cardiovascular homeostasis.
    • Operant conditioning offers a model to study volitional control over physiological parameters like blood pressure.

    Purpose of the Study:

    • To investigate the dynamic changes in baroreflex sensitivity during operant conditioning for blood pressure elevation.
    • To determine if baroreflex sensitivity is involved in the maintenance of conditioned increases in blood pressure.

    Main Methods:

    • Baroreflex sensitivity was assessed in baboons using phenylephrine injection to measure the baroreflex gain.
    • Operant conditioning involved daily 12-hour sessions to train baboons to increase diastolic blood pressure.
    • Measurements were taken before, during, and after conditioning sessions.

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    Main Results:

    • Baroreflex sensitivity showed an average increase of 32% before and after conditioning sessions.
    • During conditioning, a 17% elevation in diastolic blood pressure was associated with a 44% decrease in baroreflex sensitivity.
    • This decrease was relative to the heightened sensitivity observed outside of conditioning periods.

    Conclusions:

    • Changes in baroreflex sensitivity appear to play a role in the physiological adaptations during operantly conditioned blood pressure changes.
    • The findings suggest a dynamic interplay between volitional blood pressure control and baroreflex regulation.