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Pseudoephedrine is without ergogenic effects during prolonged exercise

H Gillies1, W E Derman, T D Noakes

  • 1Liberty Life Chair of Exercise and Sports Science, Medical Research Council/University of Cape Town Bioenergetics of Exercise Research Unit, Observatory, South Africa.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 1, 1996
PubMed
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A single dose of pseudoephedrine did not enhance exercise performance in cyclists. However, exercise did alter pseudoephedrine

Area of Science:

  • Exercise Physiology
  • Pharmacology
  • Sports Science

Background:

  • Pseudoephedrine is a common decongestant.
  • Its potential ergogenic effects in athletes are of interest.
  • Understanding drug metabolism during exercise is crucial for doping control.

Purpose of the Study:

  • To determine if pseudoephedrine enhances high-intensity exercise performance.
  • To investigate the impact of exercise on pseudoephedrine pharmacokinetics and excretion.
  • To assess the relevance for anti-doping regulations.

Main Methods:

  • Double-blind, placebo-controlled, crossover study with 10 healthy male cyclists.
  • Performance measured via 40-km time trial and isometric muscle function tests.
  • Drug and placebo administered 120 minutes before exercise; control group with drug but no exercise.

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Main Results:

  • Pseudoephedrine did not significantly affect time trial performance or muscle function.
  • Exercise significantly increased peak plasma pseudoephedrine concentrations.
  • Urinary pseudoephedrine excretion was elevated post-exercise, particularly in subjects with unaltered plasma levels during exercise.

Conclusions:

  • A single therapeutic dose of pseudoephedrine lacks a measurable ergogenic effect in 1-hour high-intensity exercise.
  • Exercise alters pseudoephedrine plasma concentrations and urinary excretion.
  • Findings have implications for doping control in sports.