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Related Experiment Videos

Smoking during pregnancy: Missouri longitudinal study

W F Schramm1

  • 1Bureau of Health Data Analysis, Missouri Department of Health, Jefferson City 65101, USA.

Paediatric and Perinatal Epidemiology
|January 1, 1997
PubMed
Summary

Maternal smoking in second pregnancies significantly increases low birthweight risk, even if not smoking in the first. Smoking in both pregnancies shows the highest risk for adverse birth outcomes.

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Factors associated with repetition of low birthweight: Missouri longitudinal study.

Paediatric and perinatal epidemiology·1997

Area of Science:

  • Obstetrics and Gynecology
  • Public Health
  • Perinatal Epidemiology

Background:

  • Maternal smoking during pregnancy is a known risk factor for adverse birth outcomes.
  • Previous research indicates associations with reduced birthweight and increased fetal/infant mortality.
  • Understanding smoking patterns across successive pregnancies is crucial for targeted interventions.

Purpose of the Study:

  • To examine maternal smoking patterns in first and second singleton pregnancies.
  • To assess the impact of smoking in one or both pregnancies on second pregnancy outcomes.
  • To quantify the risks of low birthweight, small-for-gestational age, and mortality associated with maternal smoking.

Main Methods:

  • Analysis of maternally-linked singleton pregnancy data from 176,843 Missouri women (1978-1990).
  • Known smoking status was recorded for both first and second pregnancies.
  • Multivariate logistic regression was used to analyze the relationship between smoking and pregnancy outcomes.

Main Results:

  • Women were more likely to smoke in their second pregnancies (27.4%) than their first (25.8%).
  • Smoking during the second pregnancy (only or both) significantly increased the risk of low birthweight (RR 1.82-1.87).
  • Smoking in the first pregnancy only did not significantly alter the risk of low birthweight in the second pregnancy (RR 0.97).

Conclusions:

  • Maternal smoking in the second pregnancy is a significant risk factor for low birthweight.
  • Smoking cessation interventions should target women across all pregnancies, particularly the second.
  • The impact of smoking on small-for-gestational age and mortality requires further investigation.

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