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RHD antigen density and agglutination in RHD variant red cells

W A Flegel1, F F Wagner

  • 1Abteilung für Transfusionsmedizin, Universität Ulm, Germany.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|January 1, 1996
PubMed

For the Rhesus categories DIV, DVI, and DVII, agglutination was compared to the number of RHD antigens per cell. We detected 3,100 to 15,400 antigens/cell on DVI. We report examples of anti-D reactivity showing lack of specificity and pointing to the known serologic split in DIV and DVI. Such a split was not found in DVII. Other examples were explained by lack of sensitivity. These results emphasized the need to consider RHD antigen densities, before a serologic split in RHD variant cells is postulated. In this context, flow cytometry may be superior to agglutination titers to determine antigen densities.

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