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Isolated liver perfusion for liver metastases: pharmacokinetic advantage?
1Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Surgical Oncology Clinics of North America
|April 1, 1996
Abstract:
The pharmacokinetic advantage of a novel system to noninvasively isolate the hepatic venous outflow and infuse high doses of chemotherapy (doxorubicin or 5-FU) is discussed and compared with intravenous infusion and intra-arterial infusion without hepatic venous detoxification. This dose intensification schema may provide new pharmacokinetic and pharmacodynamic principles for the treatment of a variety of tumors metastasizing the liver, including melanoma, sarcoma, and adenocarcinoma.