[Regulation and physiopathology of phosphate transport]

Renal phosphate transport is subjected to a fine tuning which involves hormones and local mediators and results in adaptation of excretion to dietary contents. Recent insights into the molecular structure of phosphate transporters have shed light on the mechanisms which underline the effects of these mediators. Another important repercussion of these advances is the identification of pathological states such as renal phosphate leaks and the elaboration of diagnostic and therapeutic strategies aiming to improve these troubles.