Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myasthenia gravis

A Marx1, A Schultz, A Wilisch

  • 1Department of Pathology, University of Würzburg.

Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantum Teleportation over Thermal Microwave Network.

Physical review letters·2026
Same author

[Guide to the application of the 9th TNM classification for lung cancer : Statement/position paper of the Thoracic Pathology Working Group].

Pathologie (Heidelberg, Germany)·2025
Same author

Parity-dependent state transfer for direct entanglement generation.

Nature communications·2025
Same author

Ythdf2 regulates cardiac remodeling through its mRNA target transcripts.

Journal of molecular and cellular cardiology·2023
Same author

Effect of feeding histidine and β-alanine on carnosine concentration, growth performance, and meat quality of broiler chickens.

Poultry science·2021
Same author

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison.

Science advances·2021
Same journal

[The PEA-15 protein induces resistance against glucose deprivation-induced cell death via the ERK/MAP kinase pathway].

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
Same journal

[Methylation status of LINE-1 sequences in patients with MDS or secondary AML].

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
Same journal

[Heat shock protein 90 alpha und beta are overexpressed in multiple myeloma cells and critically contribute to survival].

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
Same journal

[Gastrin cell hyperplasia associated with duodenal MEN1-related gastrinomas: histopathology and genetics].

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
Same journal

Artificial intelligence and bladder cancer arrays.

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
Same journal

[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR].

Verhandlungen der Deutschen Gesellschaft fur Pathologie·2008
See all related articles

Myasthenia gravis (MG) involves autoimmune attacks on the acetylcholine receptor (AChR), often linked to thymus abnormalities. Research suggests thymic microenvironments, whether inflammatory or neoplastic, initiate MG pathogenesis.

Area of Science:

  • Immunology
  • Neurology
  • Pathology

Background:

  • Myasthenia gravis (MG) is a human autoimmune disease targeting the acetylcholine receptor (AChR).
  • MG is consistently associated with pathological changes in the thymus.
  • The thymus plays a critical role in T cell development and immune tolerance.

Purpose of the Study:

  • To investigate the role of thymic microenvironments in the pathogenesis of myasthenia gravis.
  • To differentiate the mechanisms of autoimmunity in MG associated with thymitis versus thymomas.
  • To explore the potential role of molecular mimicry in thymoma-associated MG.

Main Methods:

  • Analysis of thymic pathology in distinct models of autoimmunization against AChR.
  • Examination of B cell infiltrates and autoantibody production within the thymus in MG with thymitis.

Related Experiment Videos

  • Investigation of antigen presentation and T cell selection in thymomas.

    • Main Results:

    • In MG with thymitis, increased B cells and intrathymic production of AChR-specific autoantibodies occur.
    • In thymomas, AChR is not the primary autoantigen; molecular mimicry involving neurofilaments may trigger autoimmunity.
    • Abnormal thymic microenvironments (inflammatory or neoplastic) are implicated in initiating MG.

    Conclusions:

    • The thymus is a critical site for the initiation of myasthenia gravis pathogenesis.
    • Distinct mechanisms drive autoimmunity in thymitis-associated MG and thymoma-associated MG.
    • Further research is needed to elucidate the enigmatic etiology of myasthenia gravis.