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Resorbable coupling fixation in craniosynostosis surgery: experimental and clinical applications
1Craniofacial Program, Indiana University Medical Center, Indianapolis, IN 46202-5200, USA.
The Journal of Craniofacial Surgery
|November 1, 1995
Summary
Resorbable bone fixation devices made from polyglycolic acid and polylactic acid show promise. These devices were successfully used in rabbits and infants, promoting bone growth and healing without complications.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Pediatric Neurosurgery
Background:
- Resorbable polymers offer an alternative to permanent fixation in pediatric bone surgery.
- Polyglycolic acid and polylactic acid copolymers are well-established for medical applications.
Purpose of the Study:
- To evaluate the efficacy and safety of resorbable bone fixation devices in an animal model and human infants.
- To assess the impact of these devices on bone growth and healing.
Main Methods:
- Resorbable plates and microscrews were implanted in immature rabbits to assess suture growth.
- Thin, resorbable plates were used for skeletal fixation in 20 infants with calvarial deformities following osteotomies.
Main Results:
- In rabbits, complete resorption of fixation devices and significant bone growth across the coronal suture were observed after 8 months.
- In infants, 231 devices were implanted without any complications after 12 months, indicating successful skeletal fixation.
Conclusions:
- Resorbable bone fixation devices composed of polyglycolic acid and polylactic acid are safe and effective for pediatric craniofacial applications.
- These devices facilitate bone healing and growth, showing potential for treating craniosynostosis and other deformities.