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Complete inventory of the yeast ABC proteins
1Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Nature Genetics
|February 1, 1997
Summary
Researchers classified 29 yeast ATP-binding cassette (ABC) proteins into six clusters. This classification offers insights into the function of human ABC proteins involved in various diseases and cellular processes.
Area of Science:
- Biochemistry
- Genomics
- Molecular Biology
Background:
- The yeast genome encodes 29 proteins within the ATP-binding cassette (ABC) superfamily.
- ABC proteins are crucial for diverse cellular functions across eukaryotes.
Purpose of the Study:
- To classify the 29 yeast ABC proteins.
- To understand the functional and evolutionary relationships within the yeast ABC superfamily.
- To provide insights into human homologues.
Main Methods:
- Binary comparison of protein sequences.
- Phylogenetic classification.
- Detection of conserved amino acid residues.
Main Results:
- Yeast ABC proteins were classified into six main clusters.
- Ten subclusters with distinct predicted topologies and functions were identified.
- The study identified conserved residues and phylogenetic relationships.
Conclusions:
- The classification provides a framework for understanding yeast ABC protein functions.
- Insights into yeast ABC proteins can illuminate the mechanisms of human diseases like cystic fibrosis and multidrug resistance.
- This work aids in understanding the broader roles of ABC transporters.